Tissue Lysates
Cayman Chemical 2-LInoleoyl Glycerol 1mg
A congener of 2-AG in which a linoleoyl group replaces the arachidonoyl group that potentiates the activity of other endocannabinoids, including 2-AG; this “entourage” effect has been attributed to blockade of the breakdown and reuptake pathways that normally function to rapidly reduce endocannabinoid levels following release
Cayman Chemical SynthetIc CalcItrIol 1mg
An agonist of the vitamin D3 receptor and active metabolite of vitamin D3; binds to the vitamin D3 receptor (Kd = 16 pM) and induces differentiation of U937 cells (EC50 = 2,000 pM); induces cell cycle arrest at the S phase and apoptosis in primary adenomatous and hyperplastic human parathyroid cells at 10 nM; increases bone calcium mobilization in chicks on a low calcium diet at 0.65 nmol/animal; stimulates calcium absorption in the intestines in a chick model of rickets induced by a vitamin D3-deficient diet
Cayman Chemical SynthetIc GW 9662 1mg
The peroxisome proliferator-activated receptor γ (PPARγ) is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones. Thiazolidinediones are a group of structurally related synthetic PPARγ agonists with antidiabetic actions in vivo. Rosiglitazone (BRL 49653) is a prototypical thiazolidinedione and has served as a reference compound for this class. There are many PPARγ agonists, including 15-deoxy-.DELTA.12,14-prostaglandin J2 and azelaoyl PAF, which are naturally derived. However, only a few antagonists have been reported. GW 9662 blocks the PPARγ-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1 µM. It is therefore a much more potent antagonist than BADGE, which is another reported PPARγ antagonist.
Cayman Chemical 2-ArachIdonyl Glycerol 1mg
An endogenous CB1 and CB2 receptor agonist (Kis = 25.3-472 and 145-1,400 nM, respectively); the most abundant molecular species of MAG found in rat brain; formation is calcium-dependent and is mediated by the activities of PLC and DAG lipase; induces a rapid, transient increase in intracellular free calcium in NG108-15 neuroblastoma X glioma cells through a CB1 receptor-dependent mechanism at a concentration of 0.3 nM; metabolized in vitro by MAG lipase and FAAH, with MAG lipase likely being the principle metabolizing enzyme in vivo
Cayman Chemical 14 15-EET methyl ester 100UG
An esterified version of (±)14(15)-EET; more stable for long-term storage and can be readily hydrolyzed to the free acid just before use; equipotent to (±)14(15)-EET in inducing relaxation of isolated bovine coronary arteries precontracted by U-46619
Sigma Aldrich Fine Chemicals Biosciences Aprotinin from bovine lung
Trypsin inhibitor pancreas type from bovine lung. It is known as Pancreatic trypsin inhibitor (BPTI). Aprotinin also known as pancreatic trypsin inhibitor and trypsin-kallikrein inhibitor is found to be expressed in lungs spleen liver and pancreas. It is also found to be present in the free form in calf serum.
Sino Biological Recombinant Mouse Cadherin-17 Protein (His Tag), HPLC-verified 1
A DNA sequence encoding the Mouse CDH17 (Q9R100-1) (Met1-Met786) was expressed with a C-terminal polyhistidine tag.
Abcam Lomeguatrib, MGMT inhibitor, 25MG
MW 326.17 Da, Purity >98%. Potent O⁶-methylguanine-DNA methyltransferase (MGMT) inhibitor (IC₅₀ = 9 nM). Inhibits recombinant human ATase (IC₅₀ = 5 nM). Shows antitumor effects in vivo. Enhances antitumor effects of temozolomide (ab141055).
The product is subject to the following: Abcam Restricted Use Statement
EPICYPHER INC H3K4me3 Antibody, SNAP-Certified™ for CUT&RUN and CUT&Tag, 100 µg
This H3K4me3 (histone H3 trimethylated at lysine 4) antibody meets EpiCypher’s lot-specific SNAP-Certified™ criteria for specificity and efficient target enrichment in both CUT&RUN and CUT&Tag applications. This requires <20% cross-reactivity to related histone PTMs determined using the SNAP-CUTANA™ K-MetStat Panel of spike-in controls (EpiCypher 19-1002, Figures 1 and 5). High target efficiency is confirmed by consistent genomic enrichment at varying cell inputs: 500k and 50k cells in CUT&RUN (Figures 2-3); 100k and 10k cells in CUT&Tag (Figures 6-7). High efficiency antibodies display similar peak structures (Figures 3 and 7) and highly conserved genome-wide signal (Figures 2 and 6) even at reduced cell numbers. This antibody targets histone H3K4me3, which is enriched at active promoters near transcription start sites (TSS) and promotes gene activation.
Sino Biological Recombinant Human Pin1 Protein, Biotinylated 100 µg
A DNA sequence encoding the mature form of human PIN1 (Q13526-1) (Met 1-Glu 163) was expressed and purified. The purified protein was biotinylated in vitro.
Sino Biological Recombinant Rat IL-31 Protein (His Tag), HPLC-verified 1
A DNA sequence encoding the Rat IL31 (D3ZIP0) (Ile53-Cys190) was expressed with a C-terminal polyhistidine tag.
![eMolecules 2765081-21-6 | Daraxonrasib | Ambeed | 811.06 | C44H58N8O5S | 98 | CCn1c(c2CC(C)(C)COC(=O)[C@@H]3CCCN(N3)C(=O)[C@H](Cc3nc(cs3)-c3ccc1c2c3)NC(=O)[C@H]1C[C@@H]1C)-c1cc(cnc1[C@H](C)OC)N1CCN(C)CC1 | 1mg | 874082733](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC3717418.JPG-250.jpg)
eMolecules 2765081-21-6 | Daraxonrasib | Ambeed | 811.06 | C44H58N8O5S | 98 | CCn1c(c2CC(C)(C)COC(=O)[C@@H]3CCCN(N3)C(=O)[C@H](Cc3nc(cs3)-c3ccc1c2c3)NC(=O)[C@H]1C[C@@H]1C)-c1cc(cnc1[C@H](C)OC)N1CCN(C)CC1 | 1mg | 874082733
ChemScene | 3-Methyl-4-(4-methylpiperazin-1-yl)aniline | 100mg | 536805485 | CS-0101133 | 681004-50-2 | MFCD08444067 | 205.305 | C12H19N3
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Lonza Walkersville D-HLF-COPD Fibroblasts - COPD
Diseased fibroblasts are isolated from adult COPD donors Cryopreserved Diseased Lung Fibroblast cells stain negative for von Willebrand factor VIII cytokeratins 18 and 19 and alpha smooth muscle actin All cells test negative for mycoplasma bacteria yeast and fungi HIV-1 hepatitis B and hepatitis C are not detected for all donors and/or cell lots A Certificate of Analysis is provided for each cell lot purchased